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Vitamin B6
Vitamin B6
Low concern
Vitamin B6 (pyridoxine) is FDA GRAS as a nutrient. Food intake has not been associated with adverse effects.
Found in
12,179 products
What it is
Pyridoxine (and related forms pyridoxal, pyridoxamine), a water-soluble B-vitamin essential for protein metabolism.
Nutrient fortificant; required for amino acid metabolism, neurotransmitter synthesis.
Why it's flagged
- Chronic high-dose supplementation (>200 mg/day) can cause sensory neuropathy
- Not a concern at fortification levels
What regulators actually say
"High intakes of vitamin B6 from food sources have not been reported to cause adverse effects... However, chronic administration of 1–6 g oral pyridoxine per day for 12–40 months can cause severe and progressive sensory neuropathy characterized by ataxia."
Regulatory status
United States — FDA
GRAS as nutrient (pyridoxine hydrochloride 21 CFR 184.1676)
European Union — EFSA
Authorized fortificant; UL 12 mg/day
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