Valeriana Officinalis Rhizome/Root Extract
Valerian has a long history of traditional use; NIH-ODS notes generally good tolerability in short-term studies, with mild side effects (headache, GI upset). Long-term safety data are limited.
What it is
Extract from the rhizome and root of valerian (Valeriana officinalis), containing valerenic acid and related sesquiterpenes.
Used for sedative and sleep-supporting effects in supplements; flavoring in some beverages.
Why it's flagged
- May cause drowsiness; avoid combining with sedatives or alcohol
- Limited long-term safety data
- Rare hepatotoxicity reports
What regulators actually say
"Most studies have not found side effects with valerian, but a few have reported headache, dizziness, itching, and gastrointestinal disturbances."
"The natural flavoring substances and natural substances used in conjunction with flavors... Valerian rhizome and roots (Valeriana officinalis L.)."
Regulatory status
United States — FDA
Marketed as a dietary supplement under DSHEA; valerian root permitted as a flavoring under 21 CFR 172.510
European Union — EFSA
EMA traditional herbal monograph for valerian root
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