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Transglutaminase

Low concern

Microbial transglutaminase is an FDA-GRAS enzyme processing aid. EFSA reviewed safety and considered it acceptable as a processing aid.

Found in
47 products

What it is

Enzyme (EC 2.3.2.13) that crosslinks proteins by forming covalent bonds between glutamine and lysine residues.

Texture/binding agent for restructured meat, fish, and dairy products ('meat glue').

Why it's flagged

What regulators actually say

"GRAS Notice 000004 - Microbial transglutaminase enzyme preparation - FDA had no questions on the GRAS status."

"Lerner A, Matthias T. 'Possible association between celiac disease and bacterial transglutaminase in food processing: a hypothesis.' Nutrition Reviews 2015."

Regulatory status

United States — FDA

GRAS Notice GRN 000004 (microbial transglutaminase from Streptoverticillium mobaraense) - FDA had no questions.

European Union — EFSA

Reviewed by EFSA; classified as processing aid in some uses, additive evaluation ongoing.

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