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Sassafras

High concern

FDA banned safrole and sassafras oil from food in 1960 after animal studies showed it to be a hepatocarcinogen. Safrole-free sassafras extracts and dried leaves (filé powder) remain permitted.

Found in

30 products

What it is

A tree (Sassafras albidum) whose root bark and leaves were historically used as a flavoring; safrole-containing oil prohibited in food.

Historical flavoring; safrole-free leaves used in filé powder.

Why it's flagged

Safrole is a known animal carcinogen; FDA prohibits safrole and sassafras oil in food

What regulators actually say

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Regulatory status

United States — FDA

Safrole and sassafras oil prohibited from food (21 CFR 189.180); safrole-free preparations permitted

European Union — EFSA

Safrole restricted in EU food

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