Pyridoxamine
Pyridoxamine is a natural vitamer of vitamin B6 that occurs widely in foods. NIH ODS notes vitamin B6 is essential and well tolerated at intakes within recommended ranges; the established adult tolerable upper intake level is 100 mg/day.
What it is
Pyridoxamine is one of six naturally occurring vitamers of vitamin B6, found in many foods.
Nutrient/vitamin fortificant; naturally present in animal- and plant-derived foods.
Why it's flagged
- very high B6 supplementation can cause sensory neuropathy
What regulators actually say
"Vitamin B6 in foods and dietary supplements comes in several forms, including pyridoxal, pyridoxine, and pyridoxamine. The body converts these forms into pyridoxal 5'-phosphate (PLP), which is the active coenzyme form."
Regulatory status
United States — FDA
Vitamin B6 forms are recognized nutrients; pyridoxamine dihydrochloride was determined by FDA to be excluded from the dietary supplement definition (2009).
European Union — EFSA
Vitamin B6 nutrient; UL set by EFSA.
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