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Pyridoxal 5-Phosphate

Low concern

Vitamin B6 is essential for amino acid metabolism. NIH ODS notes the adult UL is 100 mg/day; chronic intake of >1000 mg/day from supplements has caused sensory neuropathy.

Found in
67 products

What it is

The active coenzyme form of vitamin B6 (pyridoxal 5'-phosphate, P5P).

Vitamin B6 fortificant in dietary supplements and fortified foods.

Why it's flagged

What regulators actually say

"People almost always develop neurological symptoms with intakes of more than 1,000 mg/day. The UL for adults is 100 mg/day."

NIH Office of Dietary Supplements – Vitamin B6 Fact Sheet — ods.od.nih.gov

Regulatory status

United States — FDA

Permitted source of vitamin B6 in foods and supplements.

European Union — EFSA

Pyridoxal-5-phosphate authorized as a vitamin B6 source under EU Regulation 1170/2009.

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