Phytoglobin
The most prominent commercial phytoglobin, soy leghemoglobin produced in Pichia pastoris (Impossible Foods), received an FDA 'no questions' response on its GRAS notice (GRN 737) and a color additive approval (21 CFR 73.520). EFSA has not yet authorized it in the EU.
What it is
Plant-derived hemoglobin / leghemoglobin protein produced by fermentation; used to provide meat-like color and flavor in plant-based products.
Color and flavor compound providing 'bloody' / heme-iron taste in plant-based meat analogues.
Why it's flagged
- soy allergen
- novel ingredient with limited long-term human data
What regulators actually say
"FDA has no questions at this time regarding Impossible Foods' conclusion that soy leghemoglobin... is GRAS under the intended conditions of use."
"Soy leghemoglobin may be safely used as a color additive in ground beef analogue products subject to the limitations specified in this section."
Regulatory status
United States — FDA
Soy leghemoglobin GRAS notice GRN 737 received 'no questions' (2018) and approved as color additive in ground meat analogue products (21 CFR 73.520).
European Union — EFSA
Not yet authorized in the EU as a novel food.
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