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Phosphatidylserine

Low concern

Generally well-tolerated at supplemental doses (100-300 mg/day). FDA has issued qualified health claim for cognitive function.

Found in

13 products

What it is

Phospholipid component of cell membranes; supplemented form usually derived from soy or sunflower lecithin.

Dietary supplement; functional food ingredient.

Why it's flagged

Soy allergen if soy-derived

What regulators actually say

"FDA issued a qualified health claim for phosphatidylserine and reduced risk of cognitive dysfunction and dementia in the elderly with significant qualifying language regarding limited evidence."

FDA - Qualified Health Claims — fda.gov

Regulatory status

United States — FDA

Qualified health claim for cognitive dysfunction/dementia (FDA 2003); soy-PS GRAS notices accepted (e.g., GRN 122).

European Union — EFSA

Authorized; EFSA has not approved cognitive health claims.

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