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Phenylalanine

Moderate concern

Phenylalanine is a normal dietary amino acid, but people with the genetic disorder phenylketonuria (PKU) cannot metabolize it and must restrict intake. FDA requires products containing aspartame (which releases phenylalanine) to bear the warning 'PHENYLKETONURICS: CONTAINS PHENYLALANINE.'

Found in
927 products

What it is

An essential aromatic amino acid; component of the artificial sweetener aspartame and a building block of dietary protein.

Nutrient/protein component; component of aspartame.

Why it's flagged

What regulators actually say

"Any product subject to this section, which contains aspartame, must bear the statement: 'Phenylketonurics: Contains Phenylalanine.'"

"FDA has ruled that all products containing aspartame must include a warning to phenylketonurics that the sweetener contains phenylalanine."

Regulatory status

United States — FDA

Permitted; mandatory PKU warning when present via aspartame (21 CFR 172.804, 21 CFR 201.21)

European Union — EFSA

Permitted; mandatory phenylalanine declaration under EU Regulation 1169/2011

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