Methylsulfonylmethane
Also known as: dimethyl sulfone, methyl sulfone
MSM has GRAS status via FDA's no-objection letter on a GRAS notice (GRN 229), generally considered safe up to ~4–4.8 g/day. Clinical and toxicology studies show low toxicity and minimal side effects.
What it is
Methylsulfonylmethane (MSM) — an organosulfur compound (dimethyl sulfone) sold as a dietary supplement.
Dietary supplement ingredient (joint/inflammation support); also used as a drug excipient and animal feed.
Why it's flagged
- mild GI upset at high doses
- limited long-term safety data
- drug interactions not well-characterized
What regulators actually say
"FDA's CFSAN issued a response letter to a GRAS notice (GRN 229) with no objections regarding the use of MSM in foods."
"MSM is well-tolerated by most individuals at dosages of up to four grams daily, with few known and mild side effects."
Regulatory status
United States — FDA
GRAS no-objection letter (GRN 229) for use in foods
European Union — EFSA
Marketed as supplement; not an authorized novel food across all member states
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