Ilex Guayusa Leaf Extract
Guayusa is a caffeinated leaf extract similar to yerba mate. FDA granted GRAS status (GRN 893) for use as a beverage ingredient.
What it is
Extract from leaves of Ilex guayusa, an Amazonian holly tree containing caffeine and antioxidants.
Stimulant and source of caffeine in beverages and energy products.
Why it's flagged
- caffeine content
- potential interactions with stimulants
What regulators actually say
"FDA has no questions regarding the conclusion of Applied Food Sciences, Inc. that Ilex guayusa leaf extract is GRAS under the intended conditions of use as an ingredient in beverages."
"For healthy adults, the FDA has cited 400 milligrams a day as an amount not generally associated with dangerous, negative effects."
Regulatory status
United States — FDA
GRAS notice GRN 893 (no questions, 2020)
European Union — EFSA
novel food authorization required for EU
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