Home › Hypericum Perforatum Flower/Leaf/Stem Extract

Hypericum Perforatum Flower/Leaf/Stem Extract

Moderate concern

St. John's wort can cause clinically significant interactions with many prescription drugs by inducing CYP3A4 and P-glycoprotein, reducing drug efficacy.

Found in

2 products

What it is

Extract from St. John's wort (Hypericum perforatum) flowers, leaves, and stems used in cosmetics and supplements.

Botanical extract used as a skin-conditioning agent in cosmetics; also taken orally as an herbal supplement for mood. Not a typical food ingredient.

Why it's flagged

Major drug interactions (oral contraceptives, antidepressants, immunosuppressants, antiretrovirals)
Photosensitivity

What regulators actually say

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Regulatory status

United States — FDA

Marketed as a dietary supplement under DSHEA; not approved as a drug in the U.S.

European Union — EFSA

Permitted in cosmetic products under EU Cosmetics Regulation.

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