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Hydrastis Canadensis Root Extract
Hydrastis Canadensis Root Extract
Moderate concern
Goldenseal is not approved as a food additive. Berberine and hydrastine alkaloids can cause uterine stimulation, drug interactions (CYP enzyme inhibition), and contraindicated in pregnancy and infancy.
Found in
6 products
What it is
Extract of the root of Hydrastis canadensis (goldenseal), containing alkaloids berberine and hydrastine.
Botanical/herbal supplement ingredient; sometimes used in cosmetics.
Why it's flagged
- contraindicated in pregnancy
- drug-drug interactions via CYP3A4 inhibition
- not recommended for infants
What regulators actually say
"Goldenseal can interact with prescription medications and may not be safe during pregnancy because berberine, an active component, can cross the placenta."
Regulatory status
United States — FDA
Not a food additive; sold as dietary supplement under DSHEA.
European Union — EFSA
Not authorized as a food additive; listed as a botanical of concern.
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