Hyaluronic Acid
Hyaluronic acid is generally well-tolerated as a supplement and topical ingredient. Oral intake at typical supplement doses (≤200 mg/day) has been studied for skin and joint outcomes with no major safety signals.
What it is
Glycosaminoglycan polysaccharide naturally present in skin, joints, and connective tissue.
Used as ingredient in dietary supplements and joint/skin foods; common in cosmetics.
Why it's flagged
- limited long-term safety data; potential mild GI symptoms
What regulators actually say
"The Panel concludes that the novel food, sodium hyaluronate, is safe under the proposed conditions of use."
"Oral hyaluronic acid supplementation is well tolerated and may improve skin moisture in adults."
Regulatory status
United States — FDA
Generally permitted in dietary supplements and cosmetics
European Union — EFSA
Novel food evaluations; safe at proposed uses
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