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Huperzine A

Moderate concern

Pharmacologically active acetylcholinesterase inhibitor. NIH Office of Dietary Supplements and clinical reviews note potential for cholinergic side effects (nausea, GI upset, bradycardia) and drug interactions, especially with cholinergic and anticholinergic medications.

Found in

45 products

What it is

An alkaloid isolated from the club moss Huperzia serrata; a reversible acetylcholinesterase inhibitor.

Used as an active ingredient in dietary supplements marketed for cognition/memory; not a food additive.

Why it's flagged

pharmacologic activity
drug interactions
cholinergic side effects

What regulators actually say

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Regulatory status

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