Hesperidin
Hesperidin is a naturally occurring citrus flavonoid with extensive food consumption history through citrus fruits. EFSA has evaluated hesperidin and concluded it is safe at proposed supplement doses.
What it is
A flavanone glycoside found abundantly in citrus peel, especially oranges and lemons.
Bioflavonoid dietary ingredient; used in supplements and functional foods, sometimes for vascular health claims.
Why it's flagged
- potential mild interaction with calcium-channel blockers (theoretical)
What regulators actually say
"EFSA NDA Panel evaluated health claims related to hesperidin and concluded it is a normal constituent of citrus consumption with no specific safety concerns at typical intakes."
Regulatory status
United States — FDA
Citrus-derived flavonoid; component of conventional foods.
European Union — EFSA
Permitted as food/food supplement; safety evaluated.
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