Grapefruit
Grapefruit is a nutritious whole fruit providing vitamin C, fiber, and lycopene (red varieties). FDA warns of significant grapefruit-drug interactions: furanocoumarins inhibit CYP3A4, altering metabolism of many medications including statins, calcium channel blockers, and immunosuppressants.
What it is
Citrus paradisi, a large citrus fruit with tart-sweet flesh.
Whole fruit and juice source.
Why it's flagged
- grapefruit-drug interactions via CYP3A4 inhibition
What regulators actually say
"Grapefruit juice can affect how some medicines work... grapefruit and grapefruit juice may cause too much or too little of those drugs in your body."
"Grapefruit, raw, pink and red - good source of vitamin C, vitamin A, and dietary fiber."
Regulatory status
United States — FDA
Whole food; FDA issues warnings about grapefruit-drug interactions
European Union — EFSA
Whole food; drug interaction warnings on relevant medications
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