Epigallocatechin Gallate
EFSA's 2018 review concluded that EGCG doses ≥800 mg/day from supplements may raise hepatic transaminases, indicating liver toxicity risk. Lower intake from brewed green tea is generally safe.
What it is
Epigallocatechin gallate (EGCG), a polyphenol catechin found primarily in green tea.
Antioxidant and bioactive constituent in green tea extracts and supplements.
Why it's flagged
- Hepatotoxicity at high doses (≥800 mg/day from supplements)
- Liver injury cases reported
What regulators actually say
"Doses of EGCG equal or above 800 mg/day taken as a food supplement have been shown to induce a statistically significant increase in serum transaminases."
"Green tea extract has been implicated in cases of clinically apparent acute liver injury including instances of acute liver failure."
Regulatory status
United States — FDA
Permitted in supplements; FDA reviewed health claim petitions
European Union — EFSA
Risk assessment 2018 identified hepatotoxicity concern at ≥800 mg/day from supplements
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