Enterococcus Faecium Ferment Filtrate
While many E. faecium strains are used safely in fermented foods and probiotics, the species is not on EFSA's QPS (Qualified Presumption of Safety) list because some clinical strains carry virulence factors and antibiotic-resistance genes (notably vancomycin resistance).
What it is
Cell-free filtrate produced by fermenting media with Enterococcus faecium bacteria; used as a postbiotic ingredient in cosmetics and some functional foods.
Skin-conditioning postbiotic / probiotic-derived ingredient; in foods sometimes used as starter culture filtrate.
Why it's flagged
- antimicrobial-resistance gene carriage in some strains
- lack of QPS status
- strain-specific safety required
What regulators actually say
"EFSA's Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) has issued guidance for the safety assessment of Enterococcus faecium, providing a new methodology for distinguishing between safe and potentially harmful strains."
"Enterococci, including E. faecium, have not been included in the list of microorganisms for Qualified Presumption of Safety (QPS) status published by EFSA."
Regulatory status
United States — FDA
Not on FDA GRAS list as a species; specific strains may have GRAS notices
European Union — EFSA
Not granted QPS status; case-by-case safety assessment per EFSA guidance
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