Advantame
Also known as: E969
Advantame was approved by FDA in 2014 as a general-purpose sweetener after safety review establishing an Acceptable Daily Intake; concerns relate primarily to its aspartame-derived structure (releases small amounts of phenylalanine), though FDA concluded labeling for phenylketonurics is not required at typical use levels.
What it is
Advantame is a high-intensity, non-nutritive sweetener structurally derived from aspartame and vanillin.
High-intensity sweetener (~20,000 times sweeter than sucrose), used in small amounts.
Why it's flagged
- Hydrolyzes to release small amounts of phenylalanine; FDA determined PKU labeling not required at expected use levels.
What regulators actually say
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Regulatory status
United States — FDA
Approved as a general-purpose sweetener and flavor enhancer in foods (except meat and poultry) under 21 CFR 172.803.
European Union — EFSA
Authorized as food additive E 969 in the EU after EFSA safety evaluation; ADI established at 5 mg/kg bw/day.
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