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Disodium Guanylate

Also known as: E627, Sodium guanylate

Low concern

Disodium guanylate is FDA GRAS and EFSA-authorized. JECFA assigned ADI "not specified." Concern is largely limited to gout/hyperuricemia patients: as a purine, it can contribute to uric acid load.

Found in

14,120 products

E-number

E627

What it is

Disodium guanylate (GMP), a flavor-enhancing nucleotide derived from yeast or fish, used synergistically with MSG.

Flavor enhancer (umami); strongly synergistic with MSG.

Why it's flagged

Purine load — caution in gout/hyperuricemia patients
Often derived from fish (allergen disclosure may apply)

What regulators actually say

"Disodium guanylate is permitted as a direct food additive used as a flavor enhancer."

21 CFR 172 - Food additives permitted for direct addition (eCFR) — ecfr.gov

Regulatory status

United States — FDA

GRAS as flavor enhancer (21 CFR 172.530)

European Union — EFSA

Authorized as E627; ADI not specified

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