Hydroxypropyl Methyl Cellulose
Also known as: E464, hypromellose, hydroxypropyl methylcellulose, HPMC, hydroxypropylmethylcellulose
HPMC (E464) is GRAS per FDA and is approved by EFSA. It is not absorbed in the gut and behaves as soluble fiber.
What it is
Hydroxypropyl methylcellulose (HPMC), a semi-synthetic cellulose ether derived from plant fibers.
Thickener, emulsifier, stabilizer, and film-former in foods, especially gluten-free and reduced-fat products.
Why it's flagged
- GI discomfort at high intake
What regulators actually say
"Hydroxypropyl methylcellulose may be safely used in food in accordance with the following prescribed conditions..."
"The Panel concluded that the proposed change in the specifications for HPMC (E 464) would not give rise to safety concerns."
Regulatory status
United States — FDA
Affirmed GRAS in 21 CFR 172.874.
European Union — EFSA
Re-evaluated; no safety concern at reported levels.
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