Tricalcium Phosphate
Also known as: E341iii, Tricalciumphosphate, tri-calcium phosphate, E 341iii, E-341iii
Tricalcium phosphate is FDA GRAS and EFSA-authorized within the group phosphate ADI of 40 mg/kg bw/day expressed as phosphorus. Concerns are dose-dependent with cumulative phosphate intake; sensitive subpopulation is chronic kidney disease.
What it is
Calcium phosphate compound (Ca3(PO4)2) used as anticaking agent, calcium fortificant, and pH regulator.
Anticaking agent, calcium source, leavening, dough conditioner; nutritional supplement in infant foods and cereals.
Why it's flagged
- cumulative phosphate burden in CKD patients
- potential nanoparticle content noted in 2023 review
What regulators actually say
"Calcium phosphate (mono-, di-, and tribasic) - generally recognized as safe when used as a nutrient or dietary supplement."
"The Panel derived a group acceptable daily intake (ADI) for phosphates expressed as phosphorus of 40 mg/kg body weight per day."
Regulatory status
United States — FDA
GRAS under 21 CFR 182.5223 / 182.8223.
European Union — EFSA
Authorized; group ADI 40 mg/kg bw/day expressed as phosphorus (2019).
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