Indigotine
Also known as: E132, indigo carmine, FD&C Blue 2, FD and C Blue 2, C.I. Food Blue 2
Authorised in US and EU. EFSA (2014) and JECFA (2019) established an ADI of 0–5 mg/kg bw/day.
What it is
Indigotine (FD&C Blue No. 2 / Indigo carmine), a synthetic disodium-sulfonated indigoid blue dye.
Blue color additive in foods, drugs, and cosmetics.
Why it's flagged
- Possible hypersensitivity reactions
- Synthetic dye
What regulators actually say
"FD&C Blue No. 2 is principally the disodium salt of 2-(1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-1H-indole-5-sulfonic acid"
"EFSA Scientific Opinion on the re-evaluation of indigo carmine (E 132) as a food additive — ADI of 5 mg/kg bw per day"
Regulatory status
United States — FDA
Approved color additive 21 CFR 74.102 (FD&C Blue No. 2)
European Union — EFSA
Authorised; ADI 5 mg/kg bw/day (EFSA 2014)
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