Disodium Guanosine-5'-Monophosphate
Also known as: sodium salts of GMP
Disodium 5'-guanylate is GRAS under FDA regulations and EFSA has confirmed no safety concern at reported use levels. It is a purine compound and product labels often advise individuals with gout or who are purine-restricted to use caution.
What it is
Disodium 5'-guanylate (E627); a sodium salt of guanosine monophosphate used as a flavor enhancer, often in combination with MSG.
Flavor enhancer producing strong umami taste, especially synergistic with MSG (E621).
Why it's flagged
- purine content - caution for gout/hyperuricemia
What regulators actually say
"Disodium guanylate may be safely used in foods as a flavor enhancer."
"The Panel evaluated the safety of guanylic acid and 5'-guanylates as food additives."
Regulatory status
United States — FDA
GRAS as a flavor enhancer (21 CFR 172.535)
European Union — EFSA
Approved as E627; re-evaluation in progress / no current safety concern at typical use
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