D-Alpha-Tocopheryl Polyethylene Glycol-1000 Succinate
Also known as: TPGS
FDA has issued GRAS notices for TPGS as a vitamin E source and absorption enhancer; widely used in pharmaceutical formulations. Standard tocopherol intake limits apply.
What it is
TPGS; a water-soluble derivative of vitamin E synthesized by esterifying d-alpha-tocopheryl succinate with polyethylene glycol 1000.
Source of vitamin E and a solubilizer/absorption enhancer in pharmaceutical and dietary supplement formulations.
Why it's flagged
- upper intake level for vitamin E (1000 mg/day adults) applies
What regulators actually say
"FDA GRAS Notice Inventory contains an accepted notice for tocopherol polyethylene glycol succinate (TPGS)."
Regulatory status
United States — FDA
GRAS notices accepted (e.g., GRN 119) for TPGS as a source of vitamin E and a solubilizer.
European Union — EFSA
Tocopherols regulated as additives (E306–E309) and vitamins under EU food law.
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