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Concentrated Grapefruit Juice

Low concern

Grapefruit juice contains furanocoumarins that inhibit intestinal CYP3A4, leading to clinically significant interactions with many medications (e.g., statins, calcium channel blockers, immunosuppressants). FDA labels for many drugs warn against grapefruit juice.

Found in

408 products

What it is

Grapefruit juice (Citrus paradisi) reduced by water removal.

Sweetener, flavor.

Why it's flagged

drug-food interactions via CYP3A4 inhibition
free sugars

What regulators actually say

"Grapefruit juice can affect how some medicines work, causing them to be either too strong or not strong enough."

FDA Consumer Update - Grapefruit Juice and Some Drugs Don't Mix — fda.gov

"Grapefruit juice is a known inhibitor of intestinal CYP3A4 and can affect drug exposure."

FDA Drug Interactions Guidance — fda.gov

Regulatory status

United States — FDA

Conventional food; FDA includes grapefruit juice interaction warnings on many drug labels

European Union — EFSA

Conventional food

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