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Citrus Paradisi Fruit Extract

Low concern

Grapefruit components inhibit intestinal CYP3A4 and can elevate blood levels of many oral medications when consumed as juice or fruit; topical cosmetic use is not associated with these interactions.

Found in

2 products

What it is

Extract from grapefruit (Citrus paradisi) fruit, used in cosmetics and flavorings.

Provides flavor, fragrance, and antioxidant phytochemicals.

Why it's flagged

Oral grapefruit can interact with many prescription medications via CYP3A4 inhibition

What regulators actually say

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Regulatory status

United States — FDA

Recognized food/flavoring ingredient.

European Union — EFSA

Recognized food; FDA and EMA have issued warnings about grapefruit-drug interactions.

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