Citrus Grandis
Whole citrus fruit, nutritious source of vitamin C and fiber. Like grapefruit, contains furanocoumarins (e.g., bergamottin) that can inhibit cytochrome P450 3A4 and significantly interact with many prescription medications.
What it is
Citrus grandis (also called Citrus maxima) — the pomelo; ancestral parent of the grapefruit.
Whole fruit consumed; peel and oils used in flavorings and cosmetics.
Why it's flagged
- furanocoumarin drug interactions (CYP3A4)
- may potentiate certain medications
What regulators actually say
"Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Certain substances in grapefruit juice block the action of CYP3A4."
"Pummelo, raw — vitamin C 61 mg per 100 g; energy 38 kcal."
Regulatory status
United States — FDA
Whole food; FDA recommends consumers read drug labels for grapefruit/pomelo interactions.
European Union — EFSA
Whole food; flavoring oils permitted under Reg. 1334/2008.
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