Citrulline
L-Citrulline at supplement doses (typically 3-8 g) appears well-tolerated in clinical studies, with mild GI symptoms occasionally reported. As a naturally occurring amino acid in foods like watermelon, dietary exposure is normal.
What it is
L-Citrulline is a non-essential amino acid that is converted to L-arginine in the body, increasing nitric-oxide-related vasodilation.
Dietary supplement ingredient used for blood-flow, exercise performance, and erectile-function support.
Why it's flagged
- mild GI upset at high doses
- limited long-term human data
What regulators actually say
"L-citrulline supplementation has been shown to improve exercise performance and reduce muscle soreness, with doses commonly ranging from 3 to 8 g."
"On the basis of the data presented, the Panel concludes that a cause and effect relationship has not been established between the consumption of L-citrulline and the claimed effects."
Regulatory status
United States — FDA
Lawful dietary ingredient under DSHEA
European Union — EFSA
Permitted in food supplements; some health claims rejected for insufficient evidence
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