Cinchona Pubescens Bark Extract
Cinchona-derived quinine causes adverse reactions including thrombocytopenia, hypersensitivity, and cardiac effects; FDA limits quinine in beverages to 83 ppm and warns against off-label medical use.
What it is
Cinchona pubescens bark extract is an extract obtained from the bark of the Cinchona pubescens tree, the natural source of quinine and other cinchona alkaloids.
Bittering agent in tonic water and certain bitter aperitifs (as part of regulated quinine/cinchona alkaloid use).
Why it's flagged
- quinine hypersensitivity
- thrombocytopenia
- contraindicated in pregnancy at therapeutic doses
What regulators actually say
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Regulatory status
United States — FDA
Quinine permitted as a natural flavoring in beverages up to 83 ppm under 21 CFR 172.575; cinchona extracts allowed in alcoholic beverages under 27 CFR.
European Union — EFSA
Quinine permitted as a flavoring in soft and alcoholic beverages with maximum levels set under EU flavoring regulations.
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