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Chrysin
Chrysin
Low concern
Chrysin is a plant flavonoid sold in dietary supplements (often marketed for testosterone/aromatase claims). Oral bioavailability is very low.
Found in
5 products
What it is
A naturally occurring flavone (5,7-dihydroxyflavone) found in passionflower, propolis, and honey.
Found endogenously in honey/propolis; not a regulated food additive but appears in dietary supplements.
Why it's flagged
- Rare hepatotoxicity reports at supplement-level doses
- Drug-interaction potential via CYP/UGT inhibition
What regulators actually say
"Chrysin has poor oral bioavailability in humans and undergoes extensive presystemic metabolism, limiting clinical effects despite in vitro activity."
Regulatory status
United States — FDA
Not GRAS-listed; sold under DSHEA dietary supplement framework
European Union — EFSA
Not authorized as a novel food additive
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