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Chromium Picolinate
Chromium Picolinate
Moderate concern
Chromium picolinate is a supplement form of trivalent chromium. NIH ODS notes evidence for glucose metabolism benefits is mixed and limited.
Found in
193 products
What it is
A synthetic compound combining trivalent chromium (Cr3+) with picolinic acid; used as a dietary supplement.
Source of supplemental chromium; marketed for glucose metabolism support.
Why it's flagged
- potential genotoxicity at high doses (picolinate ligand)
- rare hepatotoxicity case reports
- mixed evidence for marketed benefits
What regulators actually say
"Findings on the effects of chromium supplements on glucose, insulin, and HbA1c levels are mixed."
"The Panel considered that chromium picolinate may raise concern with respect to genotoxicity."
Regulatory status
United States — FDA
Permitted as a dietary supplement ingredient; nutrient content claims regulated.
European Union — EFSA
EFSA noted 2010 safety concerns about high-dose chromium picolinate.
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