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Choline Chloride

Low concern

Choline chloride is FDA GRAS as a nutrient supplement (21 CFR 182.8252). NIH ODS sets adequate intakes (550 mg/d men, 425 mg/d women) and a tolerable upper intake of 3,500 mg/d.

Found in
972 products

What it is

Quaternary ammonium salt providing the essential nutrient choline.

Nutrient supplement/fortificant; essential for membrane phospholipids and acetylcholine synthesis.

Why it's flagged

What regulators actually say

"The UL for adults is 3,500 mg/day; high intakes can cause fishy body odor, vomiting, salivation, sweating, hypotension, and hepatotoxicity."

"Choline chloride... is generally recognized as safe when used in accordance with good manufacturing practice."

Regulatory status

United States — FDA

GRAS per 21 CFR 182.8252; permitted in infant formula.

European Union — EFSA

Authorised; AI established.

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