Centella Asiatica Flower/Leaf/Stem Extract
Centella asiatica is generally regarded as safe topically and short-term orally; common side effects include rash and stomach upset. NIH LiverTox notes RARE instances of clinically apparent acute liver injury with jaundice from oral use - listed in NIH LiverTox database.
What it is
Extract from flowers, leaves, and stems of Centella asiatica (gotu kola); contains triterpenoid saponins (asiaticoside, madecassoside).
Used as a botanical extract in cosmetics for skin conditioning; also used in supplements and traditional medicine.
Why it's flagged
- rare hepatotoxicity (acute liver injury) with oral use
- potential drug interactions (sedatives, blood thinners)
- pregnancy contraindication
- long-term use safety not established
What regulators actually say
"While generally regarded as safe, Centella has been linked to rare instances of clinically apparent acute liver injury with jaundice. Common side effects include rash and an upset stomach."
"Recent articles led by authors at the National Institutes of Health (NIH) Office of Dietary Supplements (ODS) and National Center for Complementary and Integrative Health (NCCIH) have highlighted the particular challenges involved in the clinical evaluation of botanical supplements [including Centella]."
Regulatory status
United States — FDA
Cosmetic ingredient and dietary supplement under DSHEA; no FDA-approved therapeutic claims.
European Union — EFSA
Used as cosmetic ingredient; supplement use restricted in some EU member states.
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