Calcium Pyrophosphate
Calcium pyrophosphate is permitted as a food additive in some jurisdictions and as a calcium source. EFSA has assessed phosphate additives broadly; high cumulative phosphate intake is a public-health concern (EFSA reduced ADI for phosphates in 2019).
What it is
Inorganic calcium salt of pyrophosphoric acid (Ca2P2O7).
Used as a leavening acid, mineral source, or polishing agent (notably in toothpaste).
Why it's flagged
- contributes to total phosphate intake
What regulators actually say
"EFSA established a group acceptable daily intake (ADI) for phosphates of 40 mg/kg body weight per day, expressed as phosphorus."
"Calcium phosphate (mono-, di-, tribasic) listed as direct food substances generally recognized as safe."
Regulatory status
United States — FDA
Calcium pyrophosphate not specifically GRAS-affirmed for food; calcium phosphates (mono-, di-, tri-) are GRAS (21 CFR 184.1141a-c).
European Union — EFSA
Phosphates re-evaluated; group ADI 40 mg/kg bw/day (as phosphorus) set in 2019.
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