Calcium-L-Methylfolate
Calcium L-methylfolate is the bioactive form of folate used as a fortificant. It is recognized by FDA as an authorized source of folate; intakes within the Tolerable Upper Intake Level (1,000 mcg DFE/day for adults) are safe per the NIH Office of Dietary Supplements.
What it is
The calcium salt of L-5-methyltetrahydrofolate, the bioactive form of folate (vitamin B9).
Vitamin fortificant in foods and supplements as an alternative to synthetic folic acid.
Why it's flagged
- Excessive total folate intake may mask vitamin B12 deficiency
What regulators actually say
"Approximately 85% of folic acid is estimated to be bioavailable when taken with food, whereas only about 50% of folate naturally present in food is bioavailable."
Regulatory status
United States — FDA
FDA recognized L-5-methyltetrahydrofolate calcium salt as an authorized source of folate (GRAS notice GRN 000366).
European Union — EFSA
Authorized as a source of folate in foods for particular nutritional uses and food supplements per EU Regulation 1170/2009.
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