Apigenin
Apigenin is consumed in normal diets through fruits, vegetables, and herbs. Concentrated supplement use has limited human safety data but typical dietary intake is considered safe.
What it is
A naturally occurring flavone found in many plants, especially parsley, celery, chamomile, and artichoke.
Bioflavonoid present in foods; sold as a dietary supplement for various health-promoting claims.
Why it's flagged
- potential interaction with CYP450-metabolized drugs at high doses
What regulators actually say
"Apigenin is a flavonoid found in many plants and is consumed routinely in vegetables and herbs ... showing favorable safety profile at typical dietary intakes."
Regulatory status
United States — FDA
Component of conventional foods; supplement subject to DSHEA.
European Union — EFSA
Naturally present in foods; not authorized as novel food at high concentrations without evaluation.
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