Angelica Archangelica Root Extract
Angelica archangelica root contains furocoumarins (e.g., bergapten, xanthotoxin) that are phototoxic and photogenotoxic in combination with UVA. EMA's HMPC has issued reflection papers on the furocoumarin risks of A.
What it is
Extract of the root of garden angelica (Angelica archangelica), an Apiaceae botanical containing furocoumarins.
Botanical flavoring (gins, liqueurs, herbal bitters); also used in herbal/cosmetic preparations.
Why it's flagged
- photosensitization from furocoumarins
- potential photogenotoxicity at high topical doses
- drug interactions (CYP enzyme effects)
What regulators actually say
"Angelica archangelica L. preparations contain furocoumarins with a phototoxic potential."
"Regulatory limits of 1 ppm for sunscreens for which prolonged intentional exposure to UVA is foreseen and 5 ppm for other leave-on cosmetics should effectively mitigate the phototoxic risks."
Regulatory status
United States — FDA
Angelica root oil/extract FEMA GRAS as flavor; not a stand-alone FDA-approved drug
European Union — EFSA
EMA HMPC herbal monograph; SCCP furocoumarin limits in cosmetics
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