Aloe Vera
Decolorized inner-leaf aloe vera is generally considered safe for food use, but non-decolorized whole-leaf aloe vera extract was classified by IARC (NTP studies) as 'possibly carcinogenic to humans (Group 2B)' based on rodent evidence. Aloe latex (anthraquinones) has laxative effects and is no longer permitted in OTC laxatives by FDA.
What it is
Aloe vera plant (Aloe barbadensis) — used as inner-leaf gel/juice in foods and beverages, and as whole-leaf extract in supplements.
Functional/'wellness' ingredient and flavoring in beverages.
Why it's flagged
- non-decolorized whole-leaf extract IARC Group 2B
- laxative effects from aloe latex
What regulators actually say
"Under the conditions of these 2-year drinking water studies, there was clear evidence of carcinogenic activity of a nondecolorized whole leaf extract of Aloe barbadensis Miller in male and female F344/N rats."
"Whole-leaf extract of Aloe vera was classified as possibly carcinogenic to humans (Group 2B)."
Regulatory status
United States — FDA
Decolorized inner leaf permitted as food ingredient/flavoring; aloe latex not permitted as OTC laxative since 2002
European Union — EFSA
EFSA recommends restrictions on hydroxyanthracene derivatives from aloe; certain preparations not permitted as food
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