Aloe Barbadensis Leaf Extract
Non-decolorized whole-leaf Aloe vera extract showed clear evidence of carcinogenic activity in F344/N rats in NTP TR-577, leading IARC to classify whole-leaf extract as Group 2B (possibly carcinogenic to humans). Decolorized whole-leaf and inner-leaf gel preparations have far lower aloin (anthraquinone) content and are considered substantially safer.
What it is
Extract from leaves of Aloe barbadensis Miller (Aloe vera). Includes inner-leaf gel and whole-leaf extracts; chemistry differs significantly between decolorized (anthraquinone-removed) and non-decolorized forms.
Functional/herbal ingredient in beverages and supplements; cosmetic ingredient.
Why it's flagged
- non-decolorized whole-leaf extract is IARC Group 2B carcinogen (animal evidence)
- anthraquinone aloin causes intestinal irritation
- FDA banned aloe latex (anthraquinones) in OTC laxatives
What regulators actually say
"Clear Evidence of Carcinogenic Activity by a Whole-Leaf Extract of Aloe barbadensis Miller (Aloe vera) in F344/N Rats."
"Nondecolorized Whole Leaf Extract of Aloe Barbadensis Miller (Aloe Vera) Technical Report 577 - clear evidence of carcinogenic activity in male and female F344/N rats."
Regulatory status
United States — FDA
FDA banned use of aloe in OTC laxatives (2002); food use of decolorized inner-leaf preparations permitted but whole-leaf non-decolorized extracts are concerning
European Union — EFSA
EU prohibits use of preparations from leaves containing hydroxyanthracene derivatives in foods (Regulation 2021/468)
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